Polokeho eaLi-surfactant
Li-surfactants le li-metabolite tsa tsona li baka liphetoho tsa baeloji 'meleng, e leng chefo e ka bang teng le litla-morao 'meleng, ho kenyeletsoa chefo e matla, chefo ea subacute, chefo e sa foleng, litlamorao ho kemolo le ho ikatisa, chefo ea lesea le sa tsoa emoloa, teratogenicity, mutagenicity, carcinogenicity, sensitization, hemolysis le tse ling. Li-surfactants li kopana le likarolo tse fapaneng tsa 'mele oa motho ka litsela tse fapaneng, 'me litlhoko tse fapaneng li behiloe bakeng sa chefo le litla-morao tse boletsoeng ka holimo ho latela.
Li-surfactant li sebelisoa haholo lits'ebetsong tse kopanang le 'mele oa motho, joalo ka meriana, lijo, litlolo le lihlahisoa tsa bohloeki ba motho. Ka ntlafatso ea maemo a bophelo a batho, tlhokomelo e eketsehileng e lebisitsoe ho chefo le litla-morao tsa li-surfactant mefuteng e fapaneng ea ho kopana le batho. Bakeng sa merero e fapaneng ea ts'ebeliso, matšoenyeho a bohlokoa mabapi le li-surfactant a shebane haholo le ho teneha ha mucosal, ho utloa bohloko ha letlalo, chefo, chefo ea liphatsa tsa lefutso, ho ba le kankere, ho ba le teratogenicity, hemolysis, ho sileha le ho monyeha, hammoho le ho bola ha lintho tse phelang. Mohlala, lefapheng la litlolo, molao-motheo oa setso oa khetho ea metsoako o ne o beha pele litlamorao tsa botle. Ha ho khethoa li-surfactant, ho ne ho nahanoa feela ka ho fihlela mesebetsi ea mantlha e ntle joalo ka ho hloekisa, ho foamisa, ho kopanya le ho hasanya; mesebetsi ea bobeli kapa e thusang e ne e nkoa e le matšoenyeho a bobeli feela, ha ho nahanoa hanyane kapa ho se nahane ka tšusumetso ea li-surfactant boemong ba tlhaho ba letlalo le moriri. Matsatsing ana, molao-motheo oa khetho ea li-surfactants o fetohile butle-butle ho ea pele ho netefatsa tšireletso ea boemo bo tloaelehileng le bo phetseng hantle ba letlalo le moriri le ho fokotsa litlamorao tse chefo le tse mpe 'meleng oa motho, pele ho nahanoa ka mokhoa oa ho sebelisa mesebetsi e metle ea mantlha le e thusang ea li-surfactants. Mokhoa ona oa nts'etsopele o baka phephetso ho bafani ba thepa e tala ea li-surfactant, baetsi ba li-formulator le bahlahisi, ke hore, mokhoa oa ho lemoha le ho lekola polokeho le bonolo ba li-surfactants, e le ho fa bareki lihlahisoa tse sireletsehileng ka ho fetisisa, tse bobebe le tse sebetsang hantle ka ho fetisisa. Ka hona, ho hlokahala haholo ho lekola bocha polokeho le bonolo ba mefuta e teng le e mecha ea li-surfactants.
Li-surfactants tsa cationic li atisa ho sebelisoa e le li-disinfectant le li-bacteriacides, tse nang le phello e matla ea ho bolaea libaktheria tse fapaneng, hlobo le li-fungus, empa li boetse li hlahisa chefo le litla-morao ka nako e le 'ngoe. Li ka senya mesebetsi ea tsamaiso ea methapo e bohareng le tsamaiso ea ho hema, 'me tsa baka ho tlala ha mala. Li-surfactants tsa anionic li na le chefo e fokolang 'me li ke ke tsa baka kotsi e matla ea chefo 'meleng oa motho ka har'a tekanyo e tloaelehileng ea ts'ebeliso, empa ho noa ka molomo ho ka baka ho se phutholohe ha mala le letšollo. Li-surfactants tse seng tsa ionic li na le chefo e tlase kapa ha li na chefo 'me ha li na chefo ka ho nooa. Har'a tsona, li-surfactants tsa PEG li na le chefo e tlase ka ho fetisisa, e lateloa ke li-ester tsa tsoekere, AEO, Span le Tween series, ha li-alkylphenol ethoxylates li na le chefo e phahameng ka ho fetisisa.
Bakeng sa diphoofolo tsa metsing, chefo ka kakaretso ya di-surfactants tse seng tsa ionic e phahame ho feta ya di-surfactants tsa anionic.
Liteko tsa chefo ea subacute le ea chronic hangata li nka nako e telele. Ka lebaka la liphapang liphoofolong tsa liteko le maemo a mang a liteko, ho thata ho bapisa lintlha tse fapaneng. Leha ho le joalo, ka kakaretso hoa amoheloa hore liphetho tsa liteko tsa chefo ea subacute le ea chronic tsa li-surfactants tse seng tsa ionic li oela sehlopheng se seng sa chefo. Ho noa nako e telele ho ke ke ha baka likarabo tsa mafu. Ke mefuta e meng feela e ka eketsang ho monngoa ha mafura, livithamine kapa lintho tse ling 'meleng oa motho, kapa ea baka liphetoho tse ka fetoloang tsa ts'ebetso lithong tse itseng ha li nooa ka molomo ka tekanyo e phahameng. Ka hona, li-surfactants tse seng tsa ionic li ka sebelisoa e le lintho tse nang le polokeho e phahameng.
Indastering ea lijo, li-surfactant tse seng tsa ionic li atisa ho sebelisoa e le li-emulsifier. Ka linako tse ling, mesebetsi ea tsona e kang ho foamisa, ho tlosa lerōle, ho kolobisa, ho hasanya, ho thibela kristale, ho thibela botsofali, ho thibela ho tsofala, ho boloka metsi, ho bolaea likokoana-hloko le thepa ea antioxidant le eona ea hlokahala. Li-surfactant tse sebelisoang e le li-emulsifier tsa lijo li tlas'a lithibelo tse thata. Ke mefuta e 'maloa feela e amoheloang ka kakaretso bakeng sa tšebeliso, 'me e meng e lekanyelitsoe ho feta moo ke index ea Acceptable Daily Intake (ADI, mg/kg), e bolelang tekanyo e phahameng ka ho fetisisa ea sejo se itseng seo 'mele oa motho o ka se jang khafetsa ka yuniti ea boima ba' mele ntle le ho baka litlamorao tse mpe bophelong.
Li-surfactant tse seng tsa ionic li atisa ho sebelisoa e le li-solvent, li-emulsifier kapa li-suspension agents ka har'a liente tsa meriana le liente tsa limatlafatsi. Bakeng sa maemo a kenyeletsang bongata bo boholo ba ente e le 'ngoe, haholo-holo ente ea methapo, thepa ea hemolytic ea li-surfactants e tlameha ho nkoa ka botebo. Li-surfactant tsa anionic li bontša phello e matla ka ho fetisisa ea hemolytic 'me hangata ha li sebelisoe ka har'a liente; li-surfactant tsa cationic li boemong ba bobeli ts'ebetsong ea hemolytic, ha li-surfactant tse seng tsa ionic li na le bokhoni bo tlase ba hemolytic. Har'a li-surfactant tse seng tsa ionic, li-ester tsa oli ea castor tse nang le hydrogenated PEG li bontša litlamorao tse tlase tsa hemolytic 'me li loketse haholo bakeng sa ente ea methapo. Leha ho le joalo, ho eketsa tekanyo ea polymerization ea PEG ho tla fella ka ts'ebetso e phahameng ea hemolytic ho feta li-surfactant tsa mofuta oa Tween. Tatellano ea hemolytic ea li-surfactant tse seng tsa ionic ke: Tween＜Ester ea mafura a PEG＜PRG alkylphenol＜AEO. Ka har'a letoto la Tween, tatellano ea hemolytic ke: Pakeng tsa 80.
Nako ea poso: Mots'eanong-12-2026